Subgroup Analysis of Topical Tranexamic Acid in Total Knee Arthroplasty

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Tranexamic Acid and Total Knee Arthroplasty

Total knee arthroplasty (TKA) is one of the most commonly performed elective orthopaedic procedures in the United States [1]. By 2030, the number is estimated to grow by 673% to 3.48 million TKAs performed a year [1]. TKA provides significant pain relief and improvement in quality of life [2]. However TKA surgery is not without complications. Of note is the risk of bleeding and requirement for ...

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Effectiveness of tranexamic acid in revision total knee arthroplasty.

The effectiveness of Tranexamic Acid (TXA, antifibrinolytic drug) in reducing allogeneic blood transfusion requirements has not been tested in revision total knee arthroplasty. The aim of this study was to assess the effectiveness of TXA after two intravenous doses of 1 g each. Between April 2006 and February 2010, 68 consecutive patients (19 male, 49 female) of 74 +/- 6 [m +/- SD] years of age...

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Comparative study of topical vs. intravenous tranexamic acid regarding blood loss in total knee arthroplasty☆

OBJECTIVE To compare topical vs. intravenous tranexamic acid (TA) in total knee arthroplasty regarding blood loss and transfusion. METHODS Ninety patients were randomized to receive TA intravenously (20 mg/kg in 100 mL of saline; group IV), topically (1.5 g in 50 mL of saline, sprayed over the operated site, before release of the tourniquet; topical group), or intravenous saline (100 mL with ...

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Safety and Efficacy of Tranexamic Acid in Total Knee Arthroplasty

BACKGROUND The prevalence of total knee arthroplasty (TKA) is increasing, which is one of the most frequent operations in orthopedic practice. To further investigate the safe and effective role of using tranexamic acid (TA) in reducing transfusion rate and blood loss in total knee arthroplasty. MATERIAL AND METHODS This meta-analysis was conducted according to the Cochrane methodology. Twenty...

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Topical Tranexamic Acid Reduces Blood Loss in Minimally Invasive Total Knee Arthroplasty Receiving Rivaroxaban

Background It is unclear whether topical (intra-articular) or intravenous TXA reduces blood loss in minimally invasive TKA patients receiving a direct oral anticoagulant for thromboprophylaxis. This study is to investigate whether TXA given intravenously or intra-articularly is effective in reducing blood loss in minimally invasive TKA patients using rivaroxaban for thromboprophylaxis. Method...

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ژورنال

عنوان ژورنال: Reconstructive Review

سال: 2014

ISSN: 2331-2270,2331-2262

DOI: 10.15438/rr.v4i2.72